Determining Drug Levels of Beta-lactam Antibiotics in Severe Burned Patients (MSBV)

University Hospital Schleswig-Holstein (UKSH)

Status: Completed

Conditions: Antibiotics; Severe Burn; Intensive Care

Treatments: Diagnostic Test: Drug Level Monitoring

Study type: Observational

Funder types: Other

Identifiers

NCT03335137

13-275

Details and patient eligibility

About

At antibiotic stewardship of the University Hospital of Schleswig-Holsten it was noticed that there are much less studies measuring drug levels in severe burned patients than are required. Especially, severe burned patient developing a capillary leak might show lower drug levels than patients without a capillary leak. To compare drug levels of beta-lactam antibiotics, it is the aim of this study to measure pharmacokinetics of Piperacillin/Tazobactam in ICU patients with and without severe burns.

Enrollment: 35 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

General

• Adult
• Receiving beta-lactam antibiotic Piperacillin/Tazobactam
• Antibiotic therapy of 3 or more days
• Given informed consent Group 1
• Severe Burn Group 2
• No Severe Burn

Exclusion criteria

• Already in another Study
• No useful blood sample

Trial design

35 participants in 2 patient groups

ICU Patients with Severe Burns

Description:

Patients suffering from severe burns treated on a burn unit - Drug Level Monitoring Piperacillin/Tazobactam

Treatment:

Diagnostic Test: Drug Level Monitoring

ICU Patients without Burns - Drug Level Monitoring

Description:

Patient suffering from disease treated on an ICU - Drug Level Monitoring Piperacillin/Tazobactam

Treatment:

Diagnostic Test: Drug Level Monitoring