Determining Normal Range for Free Light Chains in Serum Among Twins

University of California San Francisco (UCSF)

Status: Completed

Conditions: Multiple Myeloma

Treatments: Device: Free light chains

Study type: Interventional

Funder types: Other

Identifiers

NCT04191057

18-25508

Details and patient eligibility

About

The objective of this study is to recruit healthy adult identical and fraternal twins for the collection of one teaspoon of blood to be sent to the Clinical Lab at San Francisco General Hospital. The serum will be tested to determine the reference range for free light chains.

Full description

Serum free light chains are used to assist in the diagnosis of multiple myeloma. The test measures kappa (K) and lambda (L) chains, and the calculation of the ratio of kappa to lambda (K/L). Previous studies have shown that the K/L ratio does not change over time (1 year). The hypothesis of this study is that healthy twins will have a K/L ratio that are close to each other in value, suggesting that this ratio is genetically linked.

Enrollment: 32 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy subjects 18-80 years.
• Must be an identical or fraternal twin (both must be recruited)

Exclusion criteria

• Symptoms suggestive of multiple myeloma (e.g., renal insufficiency, anemia, bone pain) -

Trial design

Primary purpose: Screening

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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32 participants in 1 patient group

Healthy twin

Experimental group

Description:

Free light chains of twins compared to non-twin siblings

Treatment:

Device: Free light chains