Determining Normal Range for Free Light Chains in Serum Among Twins

University of California San Francisco (UCSF) logo

University of California San Francisco (UCSF)

Status

Completed

Conditions

Multiple Myeloma

Treatments

Device: Free light chains

Study type

Interventional

Funder types

Other

Identifiers

NCT04191057
18-25508

Details and patient eligibility

About

The objective of this study is to recruit healthy adult identical and fraternal twins for the collection of one teaspoon of blood to be sent to the Clinical Lab at San Francisco General Hospital. The serum will be tested to determine the reference range for free light chains.

Full description

Serum free light chains are used to assist in the diagnosis of multiple myeloma. The test measures kappa (K) and lambda (L) chains, and the calculation of the ratio of kappa to lambda (K/L). Previous studies have shown that the K/L ratio does not change over time (1 year). The hypothesis of this study is that healthy twins will have a K/L ratio that are close to each other in value, suggesting that this ratio is genetically linked.

Enrollment

32 patients

Sex

All

Ages

18 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Healthy subjects 18-80 years.
  • Must be an identical or fraternal twin (both must be recruited)

Exclusion criteria

  • Symptoms suggestive of multiple myeloma (e.g., renal insufficiency, anemia, bone pain) -

Trial design

Primary purpose

Screening

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

32 participants in 1 patient group

Healthy twin
Experimental group
Description:
Free light chains of twins compared to non-twin siblings
Treatment:
Device: Free light chains

Trial contacts and locations

1

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Central trial contact

Alan Wu, PhD; Bee Ong

Data sourced from clinicaltrials.gov

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