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Determining the Relationship Between the Atherosclerosis and Periodontopathogenic Microorganisms

I

Izmir Katip Celebi University

Status

Completed

Conditions

Chronic Periodontitis
Atherosclerosis

Treatments

Procedure: Non-surgical periodontal treatment

Study type

Interventional

Funder types

Other

Identifiers

NCT02977351
IzmirKCU

Details and patient eligibility

About

Determine the relationship between the systemic indications of atherosclerosis by means of the change in the ratio of periodontopathogenic microorganisms following periodontal treatment of individuals who have been diagnosed with chronic periodontitis-atherosclerosis and for individuals who have been diagnosed with systemically healthy-chronic periodontitis.

Full description

It has been aimed in this study to compare 1) the change in periodontal status; 2) the change of the periodontopathogen microorganisms (A. actinomycetemcomitans, P. gingivalis, T. forsythia, T. denticola, P. intermedia, P. micros, F. nucleatum/periodonticum, C. rectus, E. nodatum, E. corrodens, and C. gingivalis/ochracea/sputigena) in dental plaque samples, 3) the changes of the amounts of HDL, LDL, hs-CRP white blood cell levels (WBC), platelet levels (PLT), creatinine, and fibrinogen in serum samples; and 4) the correlation between periodontopathogen microorganisms (A. actinomycetemcomitans, P. gingivalis, T. forsythia, T. denticola, P. intermedia, P. micros, F. nucleatum/periodonticum, C. rectus, E. nodatum, E. corrodens, and C. gingivalis/ochracea/sputigena) and HDL, LDL, hs-CRP WBC, PLT, creatinine, and fibrinogen in patients that have been diagnosed with atherosclerosis-chronic periodontitis and systemic healthy patients and patients diagnosed with chronic periodontitis, following non surgical periodontal treatment.

Enrollment

40 patients

Sex

All

Ages

20 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • had no systemic disease,
  • had not used any antibiotics
  • had not used medications with an impact on the immune system,
  • had not received any periodontal and/or medical treatment within the last 6 months.

Exclusion criteria

  • smokers of cigarettes or other tobacco products,
  • pregnant or breastfeeding,
  • non-stable cardiovascular condition.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

40 participants in 2 patient groups

Atherosclerosis
Experimental group
Description:
Patients with atherosclerosis and chronic periodontitis
Treatment:
Procedure: Non-surgical periodontal treatment
Systemically healthy
Active Comparator group
Description:
Patients with Systemically healthy and chronic periodontitis.
Treatment:
Procedure: Non-surgical periodontal treatment

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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