Detoxification and Treatment of Subjects With Medication Overuse Headache

The New England Center for Headache, P.C.

Status and phase: Unknown; Phase 4

Conditions: Analgesic Rebound Headache

Treatments: Drug: Topiramate; Drug: Almotriptan

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00432549

CAPSS-328

Details and patient eligibility

About

The purpose of this study is to assess the benefits of almotriptan used as a transitional therapy and topiramate in subjects with medication overuse headaches (MOH.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Medication overuse headaches 18 years of age and older Must have a diagnosis of probable medication overuse headache Must have greater than fifteen headache days per month Must be in generally good health Female subjects must be postmenopausal or practicing an acceptable method of birth control

Exclusion criteria

• Not overusing six or more tablets per day of compounds containing barbituates opioids No overuse of triptans Previous failure or side effects with topiramate or almotriptan Cannot be pregnant or lactating

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind