Developing a Nutritional Supplement to Increase Collagen Synthesis in People

University of California (UC) Davis

Status: Enrolling

Conditions: Exercise; Connective Tissue; Dietary Supplements

Treatments: Dietary Supplement: Natural Product Supplement; Dietary Supplement: Placebo control

Study type: Interventional

Funder types: Other

Identifiers

NCT06138106

2110494

Details and patient eligibility

About

The purpose of this study is to test whether a natural product supplement can potentiate the increase in collagen synthesis following the ingestion of collagen protein. The investigators have developed a model of natural (GRAS certified) products that stimulate collagen synthesis, in vitro. The investigators will determine whether the natural product supplement can potentiate the collagen synthetic response to the ingestion of collagen protein. Basal and fed serum will be isolated and these samples will be used to treat human engineered ligaments.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Young healthy adults (18-30 y)

Exclusion criteria

• Pregnancy
• Smoking
• Receiving any medication that may interfere with the study outcomes

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

---

20 participants in 2 patient groups, including a placebo group

Natural Product Supplement

Experimental group

Description:

The participant will consume a dose of hydrolyzed collagen (20g) supplemented with vitamin C (100 mg), epicatechin (75 mg), vitamin E (350 iU) and stevia extract (225 mg).

Treatment:

Dietary Supplement: Natural Product Supplement

Placebo

Placebo Comparator group

Description:

The participant will consume a dose of hydrolyzed collagen (20g) supplemented with vitamin C (100 mg) and sweetener.

Treatment:

Dietary Supplement: Placebo control