Developing a Risk Assessment System of Multidrug-resistant Organisms Infection

Zhejiang University

Status: Completed

Conditions: Bacterial Infections

Treatments: Other: risk factors of infection with multidrug-resistant organisms

Study type: Observational

Funder types: Other

Identifiers

NCT04688216

2020-408

Details and patient eligibility

About

1. A retrospective analysis was performed to determine the prevalence of multidrug- resistant organisms infection in ICU from October 2017 to October 2019.
2. Non-MDRO patients were selected by random sampling in a ratio of 1:1 to the final MDRO group during the same period , and select the risk factors of infection with multi-drug resistant bacteria by comparing the two groups.
3. Randomly select 30% of the sample size as the validation set, and the remaining 70% for the training set to establish a model. Using multi-factor Logistic regression, decision tree classification, artificial neural network, support vector machine, Bayesian network Method to establish risk assessment system for multidrug-resistant organisms infection respectively.Using validation set data to calculate the area under the ROC curve (AUC) and sensitivity, specificity of models and comparing the prediction accuracy of several models. Finally, choose a more suitable risk assessment system for multidrug-resistant organisms infection.
4. Predict the patient's infection risk level according to the best risk assessment system and develop a low-to-high intervention plan.

Enrollment: 917 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria：

• Duration of ICU admission ≥ 48h
• no less than 18 years old

Exclusion Criteria:

• Patients with MDRO infection at the time of admission
• Lack of case data
• MDRO colonized patients

Trial design

917 participants in 2 patient groups

MDRO

Treatment:

Other: risk factors of infection with multidrug-resistant organisms

Non-MDRO

Treatment:

Other: risk factors of infection with multidrug-resistant organisms