Developing Methods for Reconstructing Electrical Heart Activity

Maastricht University Medical Centre (MUMC)

Status: Unknown

Conditions: Cardiac Conduction Defect; Heart Diseases

Treatments: Radiation: Computed tomography (CT) scan; Device: Body-surface potential mapping

Study type: Interventional

Funder types: Other

Identifiers

NCT03947021

METC 11-2-043

NHS 2007T51 (Other Grant/Funding Number)

Details and patient eligibility

About

Non-invasive reconstruction of electrical heart activity can yield important scientific and clinical insights in cardiac rhythm disorders. In this study, The investigators aim at developing methods for reconstructing electrical heart activity non-invasively, and to use these methods to investigate cardiac rhythm disorders to answer clinical and scientific questions.

Enrollment: 65 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Overall Inclusion Criteria:

• 18 years or older
• able to provide informed consent
• Conditions that might alter electrical conduction properties in the heart, including (but not limited to): Brugada syndrome (BS), Arrhythmogenic right ventricular cardiomyopathy (ARVC), demonstrated ventricular arrhythmias (resuscitation, (non)sustained ventricular tachycardia, ventricular fibrillation)
• Implanted cardiac device, such as pacemaker or implantable cardioverter defibrillator

Additional Inclusion Criteria for group 1 (CT group):

• Existing medical indication for a cardiac CT scan unrelated to this research

There are no additional inclusion criteria for group 2 (no-CT group).

Exclusion Criteria:

• Known strong reaction against electrode attachment

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

65 participants in 2 patient groups

BSPM-only group

Experimental group

Description:

Participants will only receive body-surface potential mapping (BSPM) with an extensive electrode set (256 electrodes).

Treatment:

Device: Body-surface potential mapping

CT+BSPM group

Experimental group

Description:

Participants will receive body-surface potential measurements (BSPM) and a CT scan. These data will allow for non-invasive reconstruction of electrical potentials at the heart surface.

Treatment:

Radiation: Computed tomography (CT) scan

Device: Body-surface potential mapping