Developing Mouse Models of Breast Cancer Using Tissue Samples From Women With Breast Cancer
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About
RATIONALE: Changing the genes in laboratory mice to create a living model of human breast cancer may help doctors learn more about breast cancer.
PURPOSE: This research study is developing mouse models of breast cancer using tissue samples that were previously collected from women with breast cancer.
Full description
OBJECTIVES:
- To develop new in vivo models of human breast cancer.
- To correlate response in this model to actual treatment outcome in patients, if the in vivo model is proven feasible.
OUTLINE: Previously collected breast tumor fragments are implanted into the renal capsule site of SCID mouse hosts (mouse with severe combined immune deficiency) to establish metastatic spread patterns, and both histologic and molecular tumor characteristics.
Patients' medical charts are reviewed to obtain relevant information, including general demographics, smoking and alcohol use, as well as outcome data such as survival and response to treatment.
Enrollment
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Inclusion and exclusion criteria
DISEASE CHARACTERISTICS:
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Diagnosis of breast cancer
- Any stage of disease
- Primary or metastatic disease
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Human breast tumor tissues available after the diagnoses have been made
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Enrolled on the ongoing Breast Tissue Repository trial VU-VICC-BRE-03103
- Have consented to the use of their tissues for research purpose
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Hormone receptor status not specified
PATIENT CHARACTERISTICS:
- Menopausal status not specified
PRIOR CONCURRENT THERAPY:
- Not specified
Trial design
26 participants in 1 patient group
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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