Development and Evaluation of a Cognitive Rehabilitation Program for Persons With Multiple Sclerosis

Tel Aviv University

Status: Unknown

Conditions: Cognitive Impairment; Multiple Sclerosis

Treatments: Behavioral: Control intervention; Behavioral: Self-management cognitive rehabilitation group intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT01303770

MSCogRehab

PIRG03-GA-2008-230959 (Other Grant/Funding Number)

Details and patient eligibility

About

Multiple sclerosis (MS) is a progressive neurological disease that affects over 2.5 million people worldwide. Up to 50% of persons with MS (PwMS) will experience some form of cognitive impairment as a result of the disease including disturbances in memory, attention, concentration, information processing, and executive functions such as problem solving, and self-monitoring. MS-related cognitive impairments negatively affect many aspects of functioning and independent participation in everyday life. Thus, PwMS who experience cognitive impairments face a wide array of recurring barriers that pose grave challenges to carrying out everyday activities while trying to maintain multiple life roles and as they age.

Management of cognitive symptoms can be addressed through rehabilitation which has the potential to reduce disability, prevent complications of the disease, and enhance participation, independence, and quality of life. Considering the high frequency of cognitive impairments in MS and their significant, complex impact on functioning and independence, it is critical that cognitive interventions be an essential component of MS rehabilitation.

The overarching goal of this study is to develop and test a self-management, group-based cognitive rehabilitation program designed specifically for PwMS.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of MS
• 18 years of age or older
• Self-report of cognitive difficulties

Exclusion criteria

• Exacerbation of symptoms in past 3 months
• History of TBI, CVA, epilepsy, Psychiatric condition, drug/alcohol abuse

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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50 participants in 2 patient groups

Cognitive intervention group

Experimental group

Description:

Cognitive rehabilitation program designed to be tested in this study

Treatment:

Behavioral: Self-management cognitive rehabilitation group intervention

Control group

Active Comparator group

Treatment:

Behavioral: Control intervention