RaFIST: A Radiomics-Based Tool for Intratumoral Fibrosis Stratification in Non-Small Cell Lung Cancer

Jinling Hospital, China

Status: Completed

Conditions: Lung Cancer - Non Small Cell

Treatments: Other: CT radiomic analysis; Other: Fibrosis assessment

Study type: Observational

Funder types: Other

Identifiers

NCT06908005

2025-DZLC-02

Details and patient eligibility

About

Patients with suspected Lung cancer who underwent contrast-enhanced CT and pathological examinations at Center 1 between January 2011 and January 2020 and Center 2 between September 2017 and Januray 2020 were eligible for inclusion in this study.The Clinical data, preoperative clinical information, laboratory results, CT images and pathological sections were collected. The investigators also collected the disease-free survival and overall survival time. On the Deepwise multi-modal research platform, the images were semi-automatically segmented and PyRadiomics was used to extract the radiomic features. Fibrosis quantification was performed on picrosirius red (PSR)-stained tissue sections using color deconvolution and binarized collagen signal analysis in ImageJ software. The investigators developed RaFIST, a radiomics-based stratification tool, to noninvasively quantify intratumoral fibrosis in non-small cell lung cancer (NSCLC) using contrast-enhanced CT imaging. And it was further tested on the held-out external test cohort. Discrimination was assessed by using the C-index and area under the receiver operating characteristic curve (AUC).

Enrollment: 508 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Solid pulmonary nodule detected on CECT within 3 weeks pre-resection
• No history of previous treatment such as chemotherapy, or radiotherapy

Exclusion criteria

• Unavailable pathological sections
• Missing CT images or hard-to-annotate CT images
• Undergone anticancer therapy before CT
• Loss to follow-up
• Concurrent other malignant tumors

Trial design

508 participants in 2 patient groups

training set

Treatment:

Other: Fibrosis assessment

Other: CT radiomic analysis

external test set

Treatment:

Other: Fibrosis assessment

Other: CT radiomic analysis