Development and Validation of a Serum Biomarker for the Diagnostic Work-up of Asthma

Catholic University (KU) of Leuven

Status: Completed

Conditions: Asthma; Biomarkers

Treatments: Diagnostic Test: Serum biomarker testing

Study type: Interventional

Funder types: Other

Identifiers

NCT04377958

s52549

Details and patient eligibility

About

Serum samples of asthmatic patients will be screened for serum biomarkers

Enrollment: 117 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18 - 65 years
• physician-diagnosed asthma

Exclusion criteria

• No clear asthma phenotype
• Presence of other pulmonary diseases (Chronic obstructive pulmonary disease, alfa-1-antitrypsine deficiency emphysema, Immunoglobulin E deficiency, allergic bronchopulmonary aspergillosis)
• > 15 pack years
• No sputum available
• Respiratory infection
• Other inflammatory diseases (Rheumatoid Arthritis, Colitis Ulcerosa)

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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117 participants in 1 patient group

Asthmatics

Other group

Description:

Asthmatic group from which serum samples will be collected for analysis

Treatment:

Diagnostic Test: Serum biomarker testing