Development and Validation of an Early Prediction Model for Severe Mycoplasma Pneumoniae Pneumonia in Children

Capital Medical University

Status: Completed

Conditions: Mycoplasma Pneumoniae Pneumonia

Treatments: Other: medical history taking, blood test, pulmonary ultrasound

Study type: Observational

Funder types: Other

Identifiers

NCT07333833

V120250926

Details and patient eligibility

About

Pneumonia is a major threat to the health of children. Mycoplasma pneumoniae infection is a core cause of pediatric pneumonia, and the incidence of severe mycoplasma pneumoniae pneumonia (SMPP) has increased in recent years. SMPP leads to a range of extrapulmonary symptoms, including myocardial and liver injury, which may be life-threatening. Therefore, there is an urgent need to establish an early warning model for SMPP to improve the prognosis of pediatric pneumonia. This observational study aims to establish a early prediction model of SMPP. Development cohorts are enrolled from Beijing Friendship Hospital between 2018-1-1 to 2024-5-31, and validation cohorts are enrolled between 2024-6-1 to 2025-6-30.

Enrollment: 964 patients

Sex: All

Ages: 1 month to 14 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age between 1 month to 14 years
• diagnosed with Mycoplasma pneumoniae pneumonia
• hospital stay ≥ 72 hours

Exclusion criteria

• pulmonary chronicles
• cardiovascular conditions
• inherited metabolic disorders
• immuno-deficiency disorders
• coinfection with pathogens other than Mycoplasma pneumoniae

Trial design

964 participants in 3 patient groups

Development

Description:

A primary cohort of eligible patients from the Beijing Friendship Hospital between 2018-1-1 and 2024-5-31 is used for model derivation.

Treatment:

Other: medical history taking, blood test, pulmonary ultrasound

Internal cross-validation

Description:

A cohort of consecutive patients from the Beijing Friendship Hospital between 2018-1-1 and 2024-5-31 is used for internal cross-validation.

Treatment:

Other: medical history taking, blood test, pulmonary ultrasound

External validation

Description:

A cohort of patients from the Beijing Friendship Hospital between 2024-6-1 and 2025-6-30 is used for internal cross-validation.

Treatment:

Other: medical history taking, blood test, pulmonary ultrasound