Development and Validation Phase of Diffusion Tensor Imaging and Arterial Spin Labelling at 3 Tesla Using a Long-term Effort Model Applicable to Skeletal Muscle Characterization.

University Hospital Center (CHU)

Status: Completed

Conditions: Marathoners

Treatments: Device: Magnetic Resonance Imaging (MRI)

Study type: Interventional

Funder types: Other

Identifiers

NCT02018718

9097

Details and patient eligibility

About

The aim of this study is to demonstrate and quantify the micro architecture and micro vascular changes within skeletal muscles after marathon using 3T MRI (diffusion tensor and arterial spin labeling). Apparent diffusion coefficient, fractional anisotropy and flow parameters will be registered before and after the long-distance run on the lower leg. Axial T1 and axial SPAIR sequences will also be applied at the same time.Stress ox and inflammatory markers will be collected in blood and urine samples and compare with both MRI and Near-infrared spectroscopy (NIRS).

Enrollment: 25 patients

Sex: Male

Ages: 25 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Realizing between 2:10 and 4:30 in the marathon.

Exclusion criteria

• Smoker
• Subject with medical treatment or with a treatment interrupted for less than 30 days.
• Subject with a osteo-articular, cardiovascular, infectious, lung pathology and/or a metabolic chronic pathology.
• MRI Contraindication : Claustrophobic subject ; subject with a intra-cranial vascular clip, with a pacemaker, with a neurostimulator or a cochlear implant ; subject with intraocular metallic foreign bodies.

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

25 participants in 1 patient group

Marathoners

Other group

Treatment:

Device: Magnetic Resonance Imaging (MRI)