Development of a Cinical and Biological Database in Ovarian, Fallopian Tube and Peritoneal Cancers (BCBOvaire)

Institut du Cancer de Montpellier - Val d'Aurelle

Status: Enrolling

Conditions: Carcinoma, Ovarian Epithelial; Fallopian Tube Neoplasms; Peritoneal Neoplasms

Treatments: Other: Biological collection

Study type: Interventional

Funder types: Other

Identifiers

NCT03976999

ICM-BDD2016/04

2016-A01041-50 (Registry Identifier)

Details and patient eligibility

About

A Clinical and Biological Database will provide to the scientific community a collection of blood and tissues with clinical datas to improve knowledge about cancer and help to develope new cancer treatments. This database is specific to epithetial ovarian cancer, Fallopian tube cancer and Primitive peritoneal cancer.

Full description

A Clinical and Biological Database is a collection of reliable, prospective and representative datas.

This collection, provided to the scientific community, will help to develope research programs such as :

• Cinicals and biological predictive factors of treatments response
• Identification of biological tumoral markers associate with survival
• Identification of prognosic factors after recidivism
• Diagnostics tests optimisation and follow-up from blood samples ( Circulating Tumor Cells (CTC) )
• Developing strong preclinical models. Those models would be later used to test alternative treatments and would help to identify new biomarkers

Enrollment: 300 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18 or older
• Patient at the diagnosis of an epithelial ovarian cancer, or a fallopian tube caner or a primitive peritoneal cancer
• Patient eligible for, at least, one surgery and a chemotherapy
• Patient having given his informed, written and express consent

Exclusion criteria

• Patient not affiliated to a social protection scheme
• Pregnant and / or nursing women
• Subject under tutelage, curatorship or safeguard of justice
• Patient whose regular follow-up is impossible for psychological, familial, social or geographical reasons

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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300 participants in 1 patient group

Biological collection

Experimental group

Description:

For all the patients include in the studie : * Blood samples collected at different times : Before treatment (T1) , after chemotherapy (T2), after interval surgery (T3) and after cancer reccurence (T4) * Tissue samples (tumor tissue and healthy tissue) collected during the surgery In parallel to this biological collection, standardized clinical data will be entered into a database

Treatment:

Other: Biological collection