Development of a Mass-spectometry Based Method for Detecting Xenon Application in Humans

Heinrich-Heine University, Duesseldorf

Status: Completed

Conditions: Anesthesia

Treatments: Drug: Anesthesia with inhalative application of xenon gas

Study type: Observational

Funder types: Other

Identifiers

NCT02105077

2014032273

Details and patient eligibility

About

The purpose of this study is to establish a laboratory method to determine from blood samples whether a person has been treated with xenon.

Full description

The noble gas xenon is used for general anesthesia in clinical routine. Recent reports indicate that xenon is also used for increasing performance in high-performance sports. The purpose of this study is to establish a method for detecting xenon exposure in humans.

In patients undergoing surgery with xenon anesthesia as part of routine hospital care, small blood samples (3ml) will be taken before anesthesia, during anaesthesia and at 1,2, 4, 8, 16, 24, 32, 40 and 48 hours after anesthesia. These blood samples will be analyzed for traces of xenon.

Enrollment: 8 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age of 18 years and older
• Xenon-based anesthesia as part of routine care

Exclusion criteria

• Inability to give written informed consent
• Known pregnancy
• Hemoglobin concentration of less than 12g/dl

Trial design

8 participants in 1 patient group

Xenon

Description:

Patients undergoing surgery with xenon-based general anesthesia

Treatment:

Drug: Anesthesia with inhalative application of xenon gas