Development of a Methodology to Design a High Order Sliding Mode Controller for Drug Dosage

Coordinación de Investigación en Salud, Mexico

Status: Unknown

Conditions: Hypertension; Diabetes; Anesthesia

Study type: Observational

Funder types: Other

Identifiers

NCT02864212

R-2014-785-063

Details and patient eligibility

About

The aim of this observational study is to create a data base to extract feature of fast-acting drugs that can be monitor in real time to design control strategies based on high order sliding mode controller to create a robust drug infusion system.

Full description

The aim of this observational study is to create a database to extract feature of fast-acting drugs that can be monitor in real time to design control strategies based on high order sliding mode controller to create a robust drug infusion system.

The observed drugs in this study are fast acting insulin, propofol and sodium nitroprusside.

The effect of insulin will be measured by a continuous glucose monitor, the effect of propofol by a bispectral index monitor and the the effect of sodium nitroprusside by a invasive blood pressure monitor.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists (ASA) physical status I, II, II

Exclusion criteria

• Impossibility to measure depth of anesthesia or invasive blood pressure. Impossibility of using glucose monitor.

Trial design

30 participants in 3 patient groups

Glucose monitoring

Description:

Glucose will be monitor in patients using fast-acting insulin.

Depth of anesthesia monitoring

Description:

Depth of anesthesia will be monitor in patients undergoing cardiac surgery.

Blood pressure monitoring

Description:

Invasive blood pressure will be monitor in patients undergoing cardiac surgery.