Development of a Model-based Working Memory Training and Investigation of Its Comparative Efficacy (sMarT)
Status
Completed
Conditions
Working Memory
Treatments
Other: single-task WM training
Other: model-based WM training
Other: sham intervention
Other: multiple-task WM training
Details and patient eligibility
About
This study is to investigate the efficacy of model-based Working Memory (WM) training using an appropriate control condition. The interventions are a model-based, a single-task and a multiple-task training on WM in order to compare the efficacies of these different training approaches for WM. A sham intervention acts as active control group. Each intervention will be presented on a tablet device.
Enrollment
131 patients
Sex
All
Ages
50+ years old
Volunteers
Accepts Healthy Volunteers
Inclusion criteria
- Informed consent as documented by signature
Exclusion criteria
- Medical history of neurological or psychiatric disorders
- Any history of substance abuse
- Color vision deficiency
- Inability to used table devices
- Montreal Cognitive Assessment < 26
Trial design
Primary purpose
Other
Allocation
Randomized
Interventional model
Parallel Assignment
Masking
Double Blind
131 participants in 4 patient groups
model-based WM training
Active Comparator group
Description:
In order to build the model-based WM training, existing tasks used to assess the different component of the Baddeley's model will be reviewed on their findings according to test-retest reliability and construct validity. For each component - phonological loop, visuospatial sketchpad, episodic buffer and central executive - the task with the highest reliability and validity will be chosen and then build the basis for the computerized training program. This procedure results in a model-based, adaptive, computerized training program for WM.
Treatment:
Other: model-based WM training
single-task WM training
Active Comparator group
Description:
The basis for the single-task training administered to the second group will be the widely used "dual-n-back training paradigm" suggested by Jaeggi et al. (2008). A complex dual n-back task including a visual and an auditory WM task will be implemented for tablet devices.
Treatment:
Other: single-task WM training
multiple-task WM training
Active Comparator group
Description:
Verbal WM tasks - particularly letter span and digit span tasks - and a visuospatial WM task are most commonly used (e.g. Dahlin et al., 2008; Klingberg et al., 2005; Westerberg et al., 2007). Therefore, a multiple-task training including these tasks will be administered to the third group.
Treatment:
Other: multiple-task WM training
sham intervention
Sham Comparator group
Description:
Active control group that as well performs a training, however not based on WM. To exclude the involvement of WM, a motor training will be administered to the control group.
Treatment:
Other: sham intervention
Trial contacts and locations
1
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Data sourced from clinicaltrials.gov
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