Development of a Molecular Diagnosing Platform for Relieving Periodontal Symptoms

General Biologicals Corporation

Status: Completed

Conditions: Periodontal Diseases; Peri-Implantitis

Study type: Observational

Funder types: Industry

Identifiers

NCT03345329

201506030

Details and patient eligibility

About

More than ninety percent of adults in Taiwan are suspected to carry periodontal disease, which causes bad breath, swollen and bleeding gums, plaque and even tooth loss. Half of the patients, however, are ignorance these clinical syndromes because of no obvious pain. In this study, the investigators selected six periodontal disease-associated bacteria strains, including Porphyromonas gingivalis (Pg), Fusobacterium nucleatum (Fn), Actinobacillus actinomycetemcomitans (Aa), Tannerella forsythia (Tf), Treponema denticola (Td) and Prevotella intermedia (Pi) as diagnostic markers. Using real-time PCR and MALDI Biotyper, the investigators will establish the database of oral microorganisms in Taiwanese people, providing periodontal disease clinical markers of high-risk groups and the basis for personal medicine of therapy in the future.

Enrollment: 100 patients

Sex: All

Ages: 25+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Age≧25
2. 3≦periodontal screening and recording≦4
3. 16 natural teeths and 6 front teeth at lesat
4. GI≧1.25
5. PI≧2

Exclusion criteria

1. People who have oral lesion, dental braces, denture, mouthwash allergy, or serious systemic disease
2. People who have ever eaten antibiotics and Anti-inflammatory drugs over the last 6 months
3. People who have ever eaten Immunosuppressive drugs, antiepileptic drugs, antihypertensive drugs, or anticoagulant
4. Pregnant women or the woman who eat birth control pills

Trial design

100 participants in 3 patient groups

Periodontal patient

Healthy person

Peri-implantitis patient