Development of a New Method for Steady-State Measurement of NO Lung Diffusing Capacity in Healthy Subjects

University Hospital Tuebingen

Status and phase: Unknown; Phase 1

Conditions: Pulmonary Diffusing Capacity

Treatments: Drug: Nitric oxide, Carbon monoxide, Helium

Study type: Interventional

Funder types: Other

Identifiers

NCT00315965

ESNOD-01

Details and patient eligibility

About

Using a rapidly responding nitric oxide analyzer in a new developed modular lung-function-setup we are going to measure steady-state NO diffusing capacity in 107 healthy subjects (age 6-45 years). The results will be compared to those measured by using carbon monoxide single-breath estimates. We like to show that the new method is sufficient to measure exactly lung diffusion capacity in this collective.

Enrollment: 107 estimated patients

Sex: All

Ages: 6 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers
• Lung function testing possible
• Written consent

Exclusion criteria

• Pulmonary, neuromuscular, cardiovascular, endocrinological illness
• Pregnancy
• Abuse of nicotine, alcohol, drugs during the last two years

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)