Development of a New Neuroimaging Method Aimed to Differentiate Mnesic Abilities of Alzheimer and Depressed Patients (RIHANNA)

Centre Hospitalier Universitaire de Besancon

Status: Unknown

Conditions: Alzheimer Disease; Depression

Treatments: Device: high-density electroencephalography

Study type: Interventional

Funder types: Other

Identifiers

NCT02840045

API/2014/51

Details and patient eligibility

About

The purpose of this study is to use a new method to differentiate mnesic abilities of early alzheimer patients and patients with a depressive disorder.

This method is based on the recording of cerebral activity while patients listen to familiar, unfamiliar and newly-learned music.

Enrollment: 30 estimated patients

Sex: All

Ages: 60+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Being right-handed
• recorded consent
• For Alzheimer patients: Mini Mental Status Examination (MMSE) score >= 18
• For patients with a depressive disorder : Major Depressive Disorder according to Diagnostic and Statistical Manual of Mental Disorders (DSM IV) and Montgomery-Asberg depression rating scale (MADRS) score >= 25
• For healthy controls : no cognitive deficit, MADRS score < 25, no depressive disorder according to DSM IV

Exclusion criteria

• Auditory deficit
• contraindication to a high-density electroencephalography exam
• refusal to participate in the study

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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30 participants in 3 patient groups

Alzheimer patients

Experimental group

Description:

Cerebral measurements from high-density electroencephalography are recorded in Alzheimer patients. The same protocol is applied in the 3 arms

Treatment:

Device: high-density electroencephalography

patients with a depressive disorder

Experimental group

Description:

Cerebral measurements from high-density electroencephalography are recorded in patients with a depressive disorder. The same protocol is applied in the 3 arms

Treatment:

Device: high-density electroencephalography

Healthy controls

Active Comparator group

Description:

Cerebral measurements from high-density electroencephalography are recorded in healthy controls

Treatment:

Device: high-density electroencephalography