Development of a Non-invasive Assessment of Skeletal Muscle Loss in Cancer Patients

The University of Texas System (UT)

Status: Completed

Conditions: Cachexia

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00994669

09-150B

5R01CA127971 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The long-term objective of this research is to develop a non-invasive approach for early assessment of which patients are at high risk for future development of skeletal muscle atrophy. The investigators hypothesize that the rate constant for the terminal portion of the isotope decay curve following ingestion of a single oral dose of deuterated-3-methylhistidine (D-3MH) provides an accurate measure of this increased risk and that this rate constant can be measured non-invasively from timed spot urine samples. In addition, the investigators hypothesize that ingestion of a meat-containing meal will stimulate synthesis of skeletal muscle proteins to a greater extent than a non-meat-containing meal.

Enrollment: 17 patients

Sex: Male

Ages: 30 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• male
• 30-85 years
• Body Mass Index (BMI) <30 kg/m2

Exclusion criteria

• Uncontrolled hypertension
• Glomerular filtration rate less than 60 mL/min/1.73 m2
• History of recurrent gastrointestinal bleeding
• Unable or unwilling to provide informed consent
• Ongoing anti-coagulant therapy

Trial design

17 participants in 2 patient groups

healthy control male

lung cancer male