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Development of Maternal Voice Recognition in Preterm Neonates (PREMAVOIX)

C

Centre Hospitalier Universitaire, Amiens

Status

Completed

Conditions

Infant, Premature

Treatments

Device: Near Infra Red Spectroscopy (NIRS)
Device: electroencephalogram (HR-EEG)

Study type

Interventional

Funder types

Other

Identifiers

NCT02818595
PI11-DR-WALLOIS

Details and patient eligibility

About

Many cognitive functions in humans are based on asymmetrical brain networks. For example, in most adults, the language is essentially processed by the left hemisphere, while other auditory functions, such as voice recognition, tend to be processed by the right hemisphere. Many studies, especially those conducted by Ghislaine Dehaene's team, have demonstrated the presence of anatomical and functional asymmetries by the first months of life. What are the causes of these asymmetries? How do they develop? Are they necessary for functioning or effective learning?

This study, conducted in collaboration with the Compiègne applied mathematics team (Abdelatif El Badia) and the INSERM team (Ghislaine Dehaene), is designed to determine the stage of development at which hemispheric dominance for voice recognition is first observed and to identify the brain structure involved in preterm neonates whose sound environment is usually very different from that of the foetus. The impact of this environment on the infant's brain development and early learning will be evaluated.

Enrollment

22 patients

Sex

All

Ages

Under 6 days old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • The distribution of children in the different groups of infants included in the study will be validated at the time of the acquisitions.
  • Normal group of children: A child meets the age criteria and without ductus arteriosus persistence ultrasound or detectable neurological disorders after clinical, neurophysiological and radiological (ETF, Scanner, MRI).
  • Group of children meet the age criteria and with cerebral neurological pathology detectable after clinical, neurophysiological and radiological (ETF, Scanner, MRI).

Exclusion criteria

About history:

  • All children with severe congenital malformation

Regarding the study period;

  • Any refusal of a parent
  • Children with severe impairment of the general condition and vital functions
  • Children with dermatitis of the face or scalp
  • Children treated with ventilation High Frequency (HFO)
  • Presence of intravenous access on the scalp (preventing the realization of the ETF, EEG and NIRS

Trial design

Primary purpose

Basic Science

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

22 participants in 2 patient groups

Normal children
Experimental group
Description:
Every child meet the age criteria and without ductus arteriosus persistence ultrasound or detectable neurological disorders after clinical, neurophysiological and radiological
Treatment:
Device: Near Infra Red Spectroscopy (NIRS)
Device: electroencephalogram (HR-EEG)
Abnormal children
Experimental group
Description:
Every child meet the criteria of age and having a detectable neurological disease after clinical, neurophysiological and radiological as intraventricular hemorrhage .
Treatment:
Device: Near Infra Red Spectroscopy (NIRS)
Device: electroencephalogram (HR-EEG)

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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