Development of New MRI Pulse Sequences for Probing Lung Function in Volunteers With Hyperpolarised 3He Gas

NHS Foundation Trust

Status and phase: Completed; Phase 1

Conditions: Healthy Volunteers

Treatments: Other: polarised 3 helium

Study type: Interventional

Funder types: Other

Identifiers

NCT01235494

STH15080

Details and patient eligibility

About

To develop techniques with MRI of Helium-3 gas to give functional images of the lungs. The goal is to test a single breath-hold functional 3-He MRI pulse sequence with sensitivity to multiple functional aspects of the luncg physiology. A group of 20 healthy volunteers willbe recruited from the local research group and the results compared with existing methods that require seperate breath-holds of 3He gas

Enrollment: 36 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age 18 -70

Exclusion criteria

• contraindication to MRI
• Resting oxygen saturation <95%
• Volunteers requiring bronchodilators less than 4 hourly
• additional respiratory diagnoses
• pregnancy

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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36 participants in 1 patient group

polarised 3 helium

Experimental group

Description:

inhaled gas

Treatment:

Other: polarised 3 helium