Development of Tumor Organoids From Undifferentiated Primary Carcinomas to Guide Therapeutic Decisions (OCAPI)

Centre Francois Baclesse

Status: Enrolling

Conditions: Undifferentiated Carcinoma

Treatments: Other: organoid etablishment

Study type: Observational

Funder types: Other

Identifiers

NCT06612827

2024-A01326-41

Details and patient eligibility

About

The study is based on the constitution of a collection of tumor and blood samples for the development of tumoroid for functional tests to predict clinical response to treatment.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient with undifferentiated primary carcinoma (UPC) with histological and immunohistochemical evidence, validated in a local and/or national UPC multidisciplinary consultation
• Patient with indication for systemic 1st-line treatment at the time of inclusion. Treatment may already have begun at the time of inclusion, but within the limit of 2 treatment cycles administered.
• Patient with life expectancy greater than 3 months
• Patient of legal age
• Patient affiliated to a social security scheme
• Signature of informed consent prior to any specific study procedure

Exclusion criteria

• Persons deprived of their liberty or under guardianship (including curatorship)
• Pregnant or breast-feeding patient

Trial design

20 participants in 1 patient group

Blood and tumor collection

Description:

Blood and tumor collection before treatment initiation

Treatment:

Other: organoid etablishment