Developmental Endothelial Locus-1, Platelet Count, and Soluble P-selectin in Overweight and Obese Subjects

Aswan University Hospital

Status: Completed

Conditions: Overweight and Obesity

Treatments: Diagnostic Test: Developmental endothelial locus-1 (DEL-1); Diagnostic Test: Platelet count; Diagnostic Test: soluble P-selectin (sP-sel)

Study type: Observational

Funder types: Other

Identifiers

NCT05864079

DEL-1 and sP-sel in obesity

Details and patient eligibility

About

This observational study aims to detect serum levels of Developmental Endothelial Locus-1 (DEL-1), Platelet Count, and Soluble P-selectin (sP-sel) in Overweight and Obese Subjects. The main questions it aims to answer are:

• Is there a difference in serum DEl-1 levels in overweight and obese subjects compared to normal subjects?
• Are there any relations between serum DEL-1 levels, sP-sel, and platelet count in overweight and obese subjects ?

Enrollment: 66 patients

Sex: Male

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male patients.
• Age (18-65) years.
• Healthy overweight and subjects.

Exclusion criteria

• Patients with cardiovascular diseases.
• Diabetic patients.
• Previous history of thrombo-embolic diseases.
• Patients with hyperthyroidism.
• Patients with any type of malignancy.
• Underlying hepatic or renal failure.
• Major surgery within 60 days.

Trial design

66 participants in 3 patient groups

Control

Description:

22 healthy age-matched normal-weight male subjects (BMI is from 18.5 to \< 25)

Treatment:

Diagnostic Test: soluble P-selectin (sP-sel)

Diagnostic Test: Platelet count

Diagnostic Test: Developmental endothelial locus-1 (DEL-1)

Overweight

Description:

22 healthy overweight male subjects (BMI is from 25 to \< 30). Patients with cardiovascular diseases, any malignancy, hepatic or renal failure, diabetic, hyperthyroid patients, patients with a previous history of thromboembolic diseases, or with a history of major surgery within 60 days will be excluded.

Treatment:

Diagnostic Test: soluble P-selectin (sP-sel)

Diagnostic Test: Platelet count

Diagnostic Test: Developmental endothelial locus-1 (DEL-1)

Obesity

Description:

22 healthy obese male subjects (BMI is ≥ 30). Patients with cardiovascular diseases, any malignancy, hepatic or renal failure, diabetic, hyperthyroid patients, patients with a previous history of thromboembolic diseases, or with a history of major surgery within 60 days will be excluded.

Treatment:

Diagnostic Test: soluble P-selectin (sP-sel)

Diagnostic Test: Platelet count

Diagnostic Test: Developmental endothelial locus-1 (DEL-1)