Dexamethasone and Block Duration in Upper Extremity

The University of Chicago

Status: Terminated

Conditions: Duration of Pain Relief

Treatments: Drug: Dexamthsone; Drug: Bupivacaine

Study type: Interventional

Funder types: Other

Identifiers

NCT01756573

IRB12-2192

Details and patient eligibility

About

Effect of dexamethasone on prolonging upper extremity block is well known. But it not known if the effect comes from its local effect on the nerves or from its general analgesic effect. In this study we will compare the systemic effect to its local effect to find out if there is a difference or not.

Enrollment: 5 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age 18-75, no contraindication to regional anesthesia,

Exclusion criteria

• opioid user, chronic pain conditions, peripheral neuropathy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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5 participants in 3 patient groups

Bupivacaine

Active Comparator group

Description:

Control

Treatment:

Drug: Bupivacaine

Bupivacaine with Dexamethasone

Experimental group

Description:

Dexamethasone will be mixed with bupivacaine

Treatment:

Drug: Dexamthsone

Drug: Bupivacaine

Intravenous Dexamethasone

Active Comparator group

Description:

Dexamethasone will be given intravenously

Treatment:

Drug: Dexamthsone

Drug: Bupivacaine