Dexamethasone Dose for Postoperative Nausea and Vomiting Prophylaxis in Obese Patients

Diskapi Yildirim Beyazit Training and Research Hospital

Status and phase: Unknown; Phase 4

Conditions: Postoperative Nausea and Vomiting

Treatments: Drug: Dexamethasone 8 mg IV; Drug: Dexamethasone 4 mg IV-control; Drug: Dexamethasone 4 mg IV

Study type: Interventional

Funder types: Other

Identifiers

NCT04538820

92/07

Details and patient eligibility

About

compare the effectiveness of different doses of dexamethasone used for postoperative nausea and vomiting prophylaxis in obese patients and in normal weight patients.

Full description

compare the effectiveness of different doses of dexamethasone used for postoperative nausea and vomiting prophylaxis in obese patients.

compare the effectiveness of dexamethasone given in 4 mg and 8 mg doses in obese patients with 4 mg doses of dexamethasone in normal weight patients.

4 mg iv dexamethasone will be administered to normal weight patients at induction of anesthesia. This group will be classified as the control group. In obese patients (BMI>30 kg/m2), one group will receive 4 mg dexamethasone and other group will receive 8 mg dexamethasone at induction.

Patients will receive general anesthesia with volatile anesthetics and tramadol will be administered IV at the end of surgery.

Postoperative nausea and vomiting, postoperative pain, blood glucose, wound infection, time to oral intake, hospital stay will be compared.

Enrollment: 150 estimated patients

Sex: Female

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

High risk patients for postoperative nausea and vomiting:

• Female
• No smoking
• BMI =18.5-24.9 for control group
• BMI >30 for other groups
• undergo laparoscopic cholecystectomy

Exclusion criteria

• Diabetes mellitus

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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150 participants in 3 patient groups

control

Active Comparator group

Description:

patients with BMI=18.5-24.9 kg/m2 will be received 4 mg dexamethasone at induction of anesthesia for postoperative nausea and vomiting prophylaxis.

Treatment:

Drug: Dexamethasone 4 mg IV-control

4 mg

Active Comparator group

Description:

patients with BMI>30 kg/m2 will be received 4 mg dexamethasone at induction of anesthesia for postoperative nausea and vomiting prophylaxis.

Treatment:

Drug: Dexamethasone 4 mg IV

8 mg

Active Comparator group

Description:

patients with BMI>30 kg/m2 will be received 8 mg dexamethasone at induction of anesthesia for postoperative nausea and vomiting prophylaxis.

Treatment:

Drug: Dexamethasone 8 mg IV