Dexamethasone Dose for Postoperative Nausea and Vomiting Prophylaxis in Obese Patients

D

Diskapi Yildirim Beyazit Training and Research Hospital

Status and phase

Unknown
Phase 4

Conditions

Postoperative Nausea and Vomiting

Treatments

Drug: Dexamethasone 8 mg IV
Drug: Dexamethasone 4 mg IV-control
Drug: Dexamethasone 4 mg IV

Study type

Interventional

Funder types

Other

Identifiers

NCT04538820
92/07

Details and patient eligibility

About

compare the effectiveness of different doses of dexamethasone used for postoperative nausea and vomiting prophylaxis in obese patients and in normal weight patients.

Full description

compare the effectiveness of different doses of dexamethasone used for postoperative nausea and vomiting prophylaxis in obese patients. compare the effectiveness of dexamethasone given in 4 mg and 8 mg doses in obese patients with 4 mg doses of dexamethasone in normal weight patients. 4 mg iv dexamethasone will be administered to normal weight patients at induction of anesthesia. This group will be classified as the control group. In obese patients (BMI>30 kg/m2), one group will receive 4 mg dexamethasone and other group will receive 8 mg dexamethasone at induction. Patients will receive general anesthesia with volatile anesthetics and tramadol will be administered IV at the end of surgery. Postoperative nausea and vomiting, postoperative pain, blood glucose, wound infection, time to oral intake, hospital stay will be compared.

Enrollment

150 estimated patients

Sex

Female

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

High risk patients for postoperative nausea and vomiting:

  • Female
  • No smoking
  • BMI =18.5-24.9 for control group
  • BMI >30 for other groups
  • undergo laparoscopic cholecystectomy

Exclusion criteria

Diabetes mellitus

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Double Blind

150 participants in 3 patient groups

control
Active Comparator group
Description:
patients with BMI=18.5-24.9 kg/m2 will be received 4 mg dexamethasone at induction of anesthesia for postoperative nausea and vomiting prophylaxis.
Treatment:
Drug: Dexamethasone 4 mg IV-control
4 mg
Active Comparator group
Description:
patients with BMI>30 kg/m2 will be received 4 mg dexamethasone at induction of anesthesia for postoperative nausea and vomiting prophylaxis.
Treatment:
Drug: Dexamethasone 4 mg IV
8 mg
Active Comparator group
Description:
patients with BMI>30 kg/m2 will be received 8 mg dexamethasone at induction of anesthesia for postoperative nausea and vomiting prophylaxis.
Treatment:
Drug: Dexamethasone 8 mg IV

Trial contacts and locations

1

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Central trial contact

Bahar SAKIZCI UYAR

Data sourced from clinicaltrials.gov

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