Dexamethasone-induced Hiccup in Chemotherapy Patients Treated by Methylprednisolone Rotation

Chung-Ang University

Status and phase: Completed; Phase 3

Conditions: Dexamethasone-induced Hiccup in Chemotherapy

Treatments: Drug: methylprednisolone

Study type: Interventional

Funder types: Other

Identifiers

NCT01974024

GSNUH 2013-1

Details and patient eligibility

About

The aims of this study were to investigate the feasibility of methylprednisolone rotation as treatment of DIH.

Full description

we planned a randomized prospective trial for cancer patients with DIH. The objective of the present study was to determine whether the rotation of corticosteroids affects the incidence and intensity of DIH without compromising the antiemetic efficacy.

Enrollment: 65 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• all solid cancer patients on chemotherapy
• age >18 years
• received dexamethasone as an antiemetic

Exclusion criteria

• brain metastases
• hiccups before dexamethasone administration
• uncontrolled diabetes mellitus
• uncontrolled esophagitis or peptic ulcer

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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65 participants in 2 patient groups

Methylprednisolone

Experimental group

Description:

Dexamethasone was replaced with methylprednisolone as an antiemetic.

Treatment:

Drug: methylprednisolone

Dexamethasone

Active Comparator group

Description:

Dexamethasone was re-administered in the cycle.

Treatment:

Drug: methylprednisolone