Dexamethasone Reduces Postoperative Emesis by Decreasing PGF2α and LTC4 Levels

Marmara University

Status: Unknown

Conditions: Breast Cancer; Thyroid Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT01811199

09.2011.0024

Details and patient eligibility

About

Hypothesis: Dexamethasone reduces postoperative emesis in thyroidectomy and mastectomy patients.

Full description

This study has been done to further study the effectiveness of dexamethasone in the prevention of postoperative emesis after breast and thyroid surgery and at the same time, the mechanism of action was investigated. In this prospective, randomized controlled trial it was hypothesized that corticosteroids exert their antiemetic effects in postoperative period via plasma prostaglandin F2 alpha (PGF2 α) and plasma leukotriene C4 (LTC4) inhibition.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• breast and thyroid cancer patients no neoadjuvant treated no NSAID or steroid usage heallthy volunteers, signed the informed consent

Exclusion criteria

• ones who did not sign the consent form NSAID or steroid users