Dexamethasone Versus Prednisolone in Acute Exacerbation of Childhood Asthma

Muhammad Aamir Latif

Status: Completed

Conditions: Acute Exacerbation of Asthma

Treatments: Drug: Prednisolone; Drug: Dexamethasone

Study type: Interventional

Funder types: Other

Identifiers

NCT07275593

DR-ASIF-MULTAN

Details and patient eligibility

About

Because of insufficient local comparative data, this study was designed to determine the outcome of intravenous dexamethasone in contrast to oral prednisolone in acute exacerbation of asthmatic children.

Full description

The findings of this study would furnish the local data. The results would also provide recommendations to use more appropriate steroid options in the local settings, resulting in aid to improve the quality of life of asthmatic children and their quicker return to daily routine activities.

Enrollment: 224 patients

Sex: All

Ages: 2 to 12 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Children of any gender
• Aged 2-12 years
• Presenting with acute exacerbation of asthma within 24-hours

Exclusion criteria

• Children with PRAM score of ≥ 10
• Used oral or parenteral corticosteroids in last 4-weeks
• With any chronic condition of lungs (TB, cystic fibrosis), liver (chronic liver disease), kidneys (chronic kidney disease, nephrotic syndrome) or blood (thalassemia, malignancy)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

224 participants in 2 patient groups

Intravenous Dexamethasone Group

Experimental group

Description:

Patients received a single IV dose of dexamethasone at a dose of 0.6 mg/kg.

Treatment:

Drug: Dexamethasone

Oral Prednisone Group

Experimental group

Description:

Patients were given oral prednisone at a dose of 2 mg/kg/day (max 60 mg) as a single dose for 3 days.

Treatment:

Drug: Prednisolone