DEXDES Trial: Dexmedetomidine-Desflurane Combination in Laparoscopic Colectomy

Tam Anh Research Institute

Status: Enrolling

Conditions: Colorectal Neoplasms

Treatments: Drug: Dexmedetomidine + Desflurane; Drug: Desflurane + Normal Saline

Study type: Interventional

Funder types: Other

Identifiers

NCT07239479

TA2.25.11

Details and patient eligibility

About

This randomized double-blind controlled clinical trial aims to evaluate the efficacy and safety of combining Dexmedetomidine with Desflurane in patients undergoing elective laparoscopic colectomy. The study will assess whether the combination can reduce Desflurane consumption, improve intraoperative hemodynamic stability, and enhance postoperative recovery compared to Desflurane alone.

Full description

Dexmedetomidine, a selective alpha-2 adrenergic agonist, has sedative and analgesic properties without significant respiratory depression. Desflurane, a volatile anesthetic with low blood-gas solubility, allows rapid induction and emergence. Combining these two agents may provide anesthetic-sparing effects and promote faster postoperative recovery under ERAS protocols. This study will enroll 40 adult patients undergoing elective laparoscopic colectomy at Tam Anh General Hospital, Vietnam. Participants will be randomized into two groups: Dexmedetomidine + Desflurane versus Desflurane alone. The primary outcome is average Desflurane consumption per hour, with secondary outcomes including hemodynamic parameters, Fentanyl use, emergence quality, and incidence of postoperative nausea and vomiting.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18-65 years
• ASA Physical Status I-II
• Elective laparoscopic colectomy
• Written informed consent provided

Exclusion criteria

• Severe cardiac, hepatic, or renal disease
• COPD or bronchial asthma
• Chronic opioid or psychotropic medication use
• Atrioventricular block (grade II-III), sick sinus syndrome
• Significant intraoperative bleeding or hemodynamic instability

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups, including a placebo group

Intervention Group

Experimental group

Description:

Arm 1 - Dexmedetomidine + Desflurane (Intervention Group): Dexmedetomidine bolus 1 µg/kg IV over 15 minutes before induction, followed by continuous infusion 0.5 µg/kg/h during surgery. Desflurane administered at 1 MAC with EtControl mode.

Treatment:

Drug: Dexmedetomidine + Desflurane

Control Group

Placebo Comparator group

Description:

Arm 2 - Desflurane + Normal Saline (Control Group): Normal saline infusion with identical timing and volume as the intervention group. Desflurane administered at 1 MAC with EtControl mode

Treatment:

Drug: Desflurane + Normal Saline