Dexketoprofen and Etoricoxib in Patients Undergoing Hip Arthroplasty (etoketo)

Kuopio University Hospital

Status and phase: Completed; Phase 4

Conditions: Pain, Postoperative

Treatments: Drug: Etoricoxib; Drug: Dexketoprofen

Study type: Interventional

Funder types: Other

Identifiers

NCT02568735

KUH30062008

Details and patient eligibility

About

The main purpose of this study was to determine the plasma and central nervious system pharmacokinetics of dexketoprofen and etoricoxib. The secondary aim was to asses their effect on the concentrations of interleukin 6, prostaglandin E2 and other proinflammatory markers both in plasma and cerebrospinal fluid. Thirdly, the investigators aimed to evaluate their efficacy in postoperative pain treatment.

Enrollment: 24 patients

Sex: All

Ages: 40 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• agreed to participate the study
• American Society of Anesthesiologist s physical status classification 1-3
• elective hip arthroplasty planned
• no contraindications to the study drugs
• no contraindication to lumbar puncture

Exclusion criteria

• refused to participate the study
• age less than 40 or over 75 years
• Planned anesthesia method other than spinal anesthesia
• contraindications to the study drugs
• Contraindications to lumbar puncture

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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24 participants in 2 patient groups

Etoricoxib

Experimental group

Description:

Etoricoxib 60mg if body weight≤ 60kg, 90mg if body weight 61-90kg and 120mg if body weight\> 90kg by mouth

Treatment:

Drug: Etoricoxib

Dexketoprofen

Active Comparator group

Description:

Dexketoprofen 0,5 mg/kg up to 50 mg intravenously

Treatment:

Drug: Dexketoprofen