Dexmedetomidine Added to Bupivacaine Versus Bupivacaine inTransincisionalU/S Guided Quadratus Lumborum Block in Open Renal Surgeries , A New Technique

Ain Shams University

Status and phase: Completed; Phase 4

Conditions: Anesthesia

Treatments: Drug: Bupivacaine; Drug: Dexmedetomidine +bupivacaine

Study type: Interventional

Funder types: Other

Identifiers

NCT03869047

FMASU R 14/2019

Details and patient eligibility

About

The purpose of this study is to compare the addition of dexmedetomidine to bupivacaine versus bupivacaine only in anterior QLblock(transincisional) , where the local anesthetic will be applied before wound closure at the end of surgery through the wound . in combination with general anesthesia in elective open renal surgery with regard to Postoperative pain control,hemodynamic stability, and adverse effects.

Enrollment: 80 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• physical status American Society of Anesthesiologist (ASA) I or II

Exclusion criteria

• Patients refusal
• A body mass index (BMI) >30 kg/m2
• ASA physical status >II
• major illnesses (e.g., cardiac, respiratory, renal, hepatic or neurological)
• Coagulation abnormalities
• Infection at the injection site
• Allergy or contraindications to the drugs used in the study
• History of drug addiction or alcohol abuse
• A psychiatric illness, or mental retardation interfering with the evaluation of pain scores or PCA programs .

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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80 participants in 2 patient groups

quadratus lumborum block(dexmedetomidine+bupivacaine)

Active Comparator group

Description:

patients will receive combined general anesthesia and Quadratuslumborum block( transincisional ie before wound closure)with 19 mL of bupivacaine 0.20%plus 1 mic/kg of dexmedetomidine ,total volume 20 ml.

Treatment:

Drug: Dexmedetomidine +bupivacaine

quadratus lumborum block(bupivacaine)

Active Comparator group

Description:

patients will receive combined general anesthesia and quadratus lumborum block (transincisional) with 20 ml of bupivacaine 0.20%.

Treatment:

Drug: Bupivacaine