Dexmedetomidine Added to Propofol for Drug Induced Sleep Endoscopy

Essam Fathi

Status and phase: Completed; Phase 4

Conditions: Obstructive Sleep Apnea of Adult

Treatments: Drug: Dexmedetomidine; Drug: Propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT03091894

3-2017-021

Details and patient eligibility

About

This study evaluate the effect of adding dexmedetomidine intravenous infusion to propofol intravenous infusion during sedation for drug induced sleep endoscopy. Twenty five patients will receive propofol only while the other twenty five will receive propofol and dexmedetomidine.

Full description

Propofol is a commonly used intravenous anesthetic drug used for procedural sedation. Dexmedetomidine is an alpha 2 adrenergic receptor agonist which has a sedative and analgesic effects.In the current study the success of the sedation during drug induced sleep endoscopy will be assessed.

Enrollment: 50 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age more than 18 years
• patients with obstructive sleep apnea
• ASA 1and2

Exclusion criteria

• patient refusal
• age less than 18 years
• morbid obesity
• known or suspected allergy to the studied drugs

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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50 participants in 2 patient groups

propofol

Active Comparator group

Description:

patients will receive only propofol intravenous infusion for sedation

Treatment:

Drug: Propofol

propofol-dex.

Active Comparator group

Description:

patients will receive dexmedetomidine in addition to propofol intravenous infusion for sedation

Treatment:

Drug: Propofol

Drug: Dexmedetomidine