Dexmedetomidine and Dexamethasone as an Adjuvant to Ropivacaine in Thoracic Surgery

University Hospital Dubrava

Status: Unknown

Conditions: Pain, Postoperative; Oxidative Stress

Treatments: Drug: Dexmedetomidine Injection [Precedex]

Study type: Interventional

Funder types: Other

Identifiers

NCT03632460

UHDubrava777

Details and patient eligibility

About

The aim of the study is to investigate the effect of preoperative epidural dexmedetomidine compared to dexamethasone on postoperative pain control, analgesic consumption and oxydative stress response in patients undergoing thoracic surgery

Full description

The aim of the study is to investigate the effect of preoperative epidural dexmedetomidine compared to dexamethasone on postoperative pain control, analgesic consumption and oxydative stress response in patients undergoing thoracic surgery.

Investigation will include patients between 30-70 years undergoing thoracic surgery due to malignant process of lung or oesophagus.

Patients are divided in two groups: epidural administration of 0.375% ropivacaine with 1 mcg/kg dexmedetomidine (group 1) and epidural administration of 0.375% ropivacaine with 8 mg dexamethasone.

Enrollment: 60 estimated patients

Sex: All

Ages: 30 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients undergoing thoracic surgery due to malignant process of lung or oesophagus ASA (American Society of Anesthesiologists) status I-III

Exclusion criteria

• neurological or psychiatric disease
• corticosteroid therapy
• anamnesis of myocardial infarct within last 6 months
• severe aortic stenosis
• kidney insufficiency
• liver insufficiency
• allergy
• coagulation disorders

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 2 patient groups

Dexmedetomidine

Active Comparator group

Description:

1 mcg/kg dexmedetomidine added to 8 ml 0.375% ropivacaine

Treatment:

Drug: Dexmedetomidine Injection [Precedex]

Dexamethasone

Active Comparator group

Description:

8 mg dexamethasone added to 8 ml 0,375% ropivacaine

Treatment:

Drug: Dexmedetomidine Injection [Precedex]

Sponsor of this trial

Lead Sponsor

University Hospital Dubrava