Dexmedetomidine as an Adjuvant to Bupivacaine for Ultrasound-Guided External Oblique Intercostal Block

Assiut University

Status: Not yet enrolling

Conditions: Opioid Consumption, Postoperative

Treatments: Drug: Dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT07263165

External Ob. intercostal block

Details and patient eligibility

About

Effect of Adding Dexmedetomidine as Adjuvant toBupivacaine in Ultrasound Guided ExternalOblique Intercostal Plane Block in UpperAbdominal Cancer Surgery.

Full description

Effect of Adding Dexmedetomidine as Adjuvant toBupivacaine in Ultrasound Guided ExternalOblique Intercostal Plane Block in UpperAbdominal Cancer Surgery. A prospectiverandomized clinical trial

Enrollment: 54 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients aged 18-70 years scheduled for elective upper abdominal cancer surgery (e.g., gastrectomy, hepatectomy, pancreatectomy).
• American Society of Anesthesiologists (ASA) physical status I-III.
• Body mass index (BMI) between 18-35 kg/m².

Exclusion criteria

• Patient refusal.
• Allergy to local anesthetics or dexmedetomidine.
• Coagulopathy (INR >1.5, platelet count <100,000/mm³).
• Infection at the injection site.
• Severe cardiopulmonary, renal, or hepatic dysfunction.
• Chronic opioid use (>30 mg morphine equivalents daily for >3 months).
• Pregnancy or lactation.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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54 participants in 2 patient groups

Dexmedetomidine + Bupivacaine

Experimental group

Description:

Participants will receive an ultrasound-guided external oblique intercostal plane block using 20 mL of 0.25% bupivacaine combined with dexmedetomidine (0.5 µg/kg) administered as a single-shot injection.

Treatment:

Drug: Dexmedetomidine

Bupivicaine

Active Comparator group

Description:

Participants will receive an ultrasound-guided external oblique intercostal plane block using 20 mL of 0.25% bupivacaine administered as a single-shot injection without any adjuvant.

Treatment:

Drug: Dexmedetomidine