Dexmedetomidine As an Adjuvant to Bupivacaine in Bilateral PECs for Pain Control After Cardiac Surgeries

Kasr El Aini Hospital

Status and phase: Enrolling; Phase 4

Conditions: Post Operative Pain

Treatments: Other: bilateral PECS; Drug: Dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT06453681

MD-75-2024

Details and patient eligibility

About

the study aims to test the quality of analgesia provided by dexmedetomidine as an adjuvant to bupivacaine bilateral PECs block in patients scheduled for cardiothoracic surgeries with median sternotomy incision.

Full description

Background: Good postoperative analgesia in cardiac surgical patients helps in early recovery and ambulation. An alternative to parenteral, paravertebral, and thoracic epidural analgesia can be pectoralis nerve (Pecs) block, which is a novel, less invasive regional analgesic technique.

The study aims to test the quality of analgesia provided by dexmedetomidine as an adjuvant to bupivacaine bilateral PECs block in patients scheduled for cardiothoracic surgeries with median sternotomy incision.

sixty adult patients between the age groups of 25 and 65 years undergoing coronary artery bypass grafting or valve surgeries through midline sternotomy under general anesthesia were enrolled in the study. Patients were randomly allocated into two groups with 30 ineach group. Group 1 patients will receive bilateral Pecs block, whereas Group 2 patients will receive bilateral Pecs block with dexameditomedine postoperatively. Patients will be extubated once they fulfilled extubation criteria. Ventilator duration will be recorded. Patients will be interrogated for pain by visual analog scale (VAS) scoring at rest and cough. Inspiratory flow rate will be assessed using incentive spirometry.

Enrollment: 60 estimated patients

Sex: All

Ages: 25 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• All adult patients between the age groups of 25 and 65 years undergoing either coronary artery bypass grafting (CABG) or valve surgeries through midline sternotomy under general anesthesia

Exclusion criteria

• Skin erosions, hematomas or infection at the injection site.
• coagulopathy, ACT more than 150 seconds
• History of hypersensitivity to bupivacaine or Dexametomedine.
• The Patients who are unable to use the pain score.
• patients who will need prolonged post-operative ventilation or inotropic support.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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60 participants in 2 patient groups

bupivacain

Active Comparator group

Description:

patients receive bilateral Pecs block with bupivacin 0.25%,

Treatment:

Other: bilateral PECS

dexameditomedine bupivacain

Active Comparator group

Description:

patients received bilateral Pecs block with bupivacin 0.25% plus dexmedetomidine 0.5 μg/Kg as adjuvant.

Treatment:

Drug: Dexmedetomidine

Other: bilateral PECS