Dexmedetomidine Combined With Lidocaine Infusion Affect Inflammation Cytokines

Anqing Municipal Hospital

Status: Completed

Conditions: Anesthesia; Reaction

Treatments: Drug: Lidocaine; Drug: Lidocaine plus Dexmedetomidine; Drug: Dexmedetomidine; Drug: Saline

Study type: Interventional

Funder types: Other

Identifiers

NCT03276533

xuzhang2013

Details and patient eligibility

About

Objective: The present study was to evaluate the effects of dexmedetomidine alone, lidocaine alone and their combined infusion on postoperative inflammation cytokines after Laparoscopic hysterectomy.

Methods: Investigators enrolled 160 women with American Society of Anesthesiologists (ASA) physical status I and II, aged 40-65 years, and scheduled for elective laparoscopic hysterectomy with general anesthesia from October 2017 to August 2018. The participants were randomly assigned into four groups(n=40 each group): group CON received normal saline infusion, group LIDO received lidocaine infusion (1.5 mg/kg loading, 1.5 mg/kg/h infusion), group DEX received dexmedetomidine infusion (0.5 µg/kg loading, 0.4 µg/kg/h infusion) and group LIDO+DEX received lidocaine (1.5 mg/kg loading, 1.5 mg/kg/h infusion) and dexmedetomidine infusions (0.5 µg/kg loading, 0.4 µg/kg/h infusion). The four groups received an IV bolus infusion of normal saline, lidocaine, dexmedetomidine and lidocaine combined with dexmedetomidine respectively, over 10 minutes before induction of anesthesia, followed by a continuous IV infusion of normal saline, lidocaine, dexmedetomidine and lidocaine combined with dexmedetomidine until abdominal wound closure, respectively. Interleukin-6 and tumor necrosis factor-α levels in serum were measured at different time points: before administration of drugs (T1), the end of surgery (T2), postoperative 2 hour (T3) and postoperative 24 hour (T4).

Enrollment: 160 patients

Sex: Female

Ages: 40 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists (ASA) physical status I and II
• weighted 50 kg-65 kg
• aged 40-65 yr
• elective laparoscopic hysterectomy with general anesthesia

Exclusion criteria

• a history of allergy to local anesthetics
• severe respiratory, renal or hepatic disease
• preoperative opioids medication
• psychiatric medical history
• Patients with severe hypotension [mean arterial pressure (MAP<60 mmHg)] or bradycardia [heart rate (HR) <40 beats per minute (bpm)], arrhythmia, or urticaria due to lidocaine and dexmedetomidine infusion during the surgery

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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160 participants in 4 patient groups

Intravenous saline, dexmedetomidine and lidocaine

Experimental group

Treatment:

Drug: Saline

Drug: Dexmedetomidine

Drug: Lidocaine

Drug: Lidocaine plus Dexmedetomidine

Intravenous saline, dexmedetomidine, lidocaine and combination

Experimental group

Treatment:

Drug: Saline

Drug: Dexmedetomidine

Drug: Lidocaine

Drug: Lidocaine plus Dexmedetomidine

Intravenous saline,dexmedetomidine plus lidocaine

Experimental group

Treatment:

Drug: Saline

Drug: Dexmedetomidine

Drug: Lidocaine

Drug: Lidocaine plus Dexmedetomidine

Intravenous saline, dexmedetomidine combined with lidocaine

Experimental group

Treatment:

Drug: Saline

Drug: Dexmedetomidine

Drug: Lidocaine

Drug: Lidocaine plus Dexmedetomidine