Dexmedetomidine Combined With Lidocaine Infusion Affect PONV

Anqing Municipal Hospital

Status: Completed

Conditions: Dexmedetomidine; Lidocaine; Nausea and Vomiting, Postoperative

Treatments: Drug: Saline infusion; Drug: lidocaine and dexmedetomidine infusion; Drug: Dexmedetomidine infusion; Drug: Lidocaine infusion

Study type: Interventional

Funder types: Other

Identifiers

NCT03809923

xuwen

Details and patient eligibility

About

BACKGROUND: Few researches have manifested that intravenous (IV) lidocaine or dexmedetomidine decreased the incidence of postoperative nausea and vomiting (PONV). The investigators investigated whether IV lidocaine plus dexmedetomidine infusion could better reduce the incidence of PONV after laparoscopic hysterectomy.

METHODS: Two hundred and forty women with elective laparoscopic hysterectomy were randomly divided into four groups: the control group (group C, n=60) received an equal volume of saline, the lidocaine group (group L, n=60) received IV lidocaine (bolus infusion of 1.5 mg/kg over 10 min, 1.5 mg/kg/h continuous infusion), the dexmedetomidine group (group D, n=60) received dexmedetomidine administration (bolus infusion of 0.5 µg/kg over 10 min, 0.4 µg/kg/h continuous infusion), the lidocaine plus dexmedetomidine group (group LD, n=60) received combination of lidocaine (bolus infusion of 1.5 mg/kg over 10 min, 1.5 mg/kg/h continuous infusion) and dexmedetomidine administration (bolus infusion of 0.5 µg/kg over 10 min, 0.4 µg/kg/h continuous infusion). Primary outcome was the incidence of the first 48 h nausea, vomiting and PONV after surgery. The secondary outcomes included perioperative propofol and remifentanil consumption, postoperative fentanyl requirement, Ramsay sedation score, and bradycardia during post-anaesthesia care unit (PACU) stay.

Enrollment: 240 patients

Sex: Female

Ages: 40 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists (ASA) physical statusⅠand Ⅱ
• Aged 40-60 years
• Scheduled for elective laparoscopic hysterectomy

Exclusion criteria

• History of allergy to local anesthetics
• BMI>30
• Severe respiratory disease
• Renal or hepatic insufficiency
• History of preoperative opioids medication and psychiatric
• preoperative bradycardia
• preoperative atrioventricular block
• Subjects who experienced severe hypotension (mean arterial pressure [MAP] <60 mmHg) or bradycardia (heart rate [HR] <40 bpm), urticaria, or arrhythmia during lidocaine and dexmedetomidine infusion period

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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240 participants in 4 patient groups

Dexmedetomidine Combined With Lidocaine Infusion Affect PONV

Experimental group

Treatment:

Drug: Dexmedetomidine infusion

Drug: Saline infusion

Drug: Lidocaine infusion

Drug: lidocaine and dexmedetomidine infusion

Effect of infusion saline on PONV

Experimental group

Treatment:

Drug: Dexmedetomidine infusion

Drug: Saline infusion

Drug: Lidocaine infusion

Drug: lidocaine and dexmedetomidine infusion

Effect of infusion lidocaine on PONV

Experimental group

Treatment:

Drug: Dexmedetomidine infusion

Drug: Saline infusion

Drug: Lidocaine infusion

Drug: lidocaine and dexmedetomidine infusion

Effect of infusion dexmedetomidine on PONV

Experimental group

Treatment:

Drug: Dexmedetomidine infusion

Drug: Saline infusion

Drug: Lidocaine infusion

Drug: lidocaine and dexmedetomidine infusion