Dexmedetomidine Dose-Dependent on Lung Function and AQP1 in One-Lung Ventilation Surgery

People's Hospital of Guangxi Zhuang Autonomous Region

Status: Completed

Conditions: Acute Lung Injury(ALI)

Treatments: Drug: 0.9 % saline; Drug: dexmedetomidine 0.5 µg/kg/h; Drug: dexmedetomidine 0.3 µg/kg/h

Study type: Interventional

Funder types: Other

Identifiers

NCT07145814

2016NXSYYEC-007

Details and patient eligibility

About

This randomized controlled trial evaluated the dose-dependent effects of dexmedetomidine (DEX) on pulmonary function and aquaporin-1 (AQP1) expression during one-lung ventilation (OLV) in thoracoscopic surgery.

Enrollment: 60 patients

Sex: All

Ages: 40 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists (ASA) physical status I or II
• Age 40-70 years
• Body mass index (BMI) 18-30 kg/m²

Exclusion criteria

• Preoperative tumor radiotherapy or chemotherapy
• Immune or endocrine disorders
• Hepatic or renal dysfunction
• Preoperative corticosteroid use
• Recent respiratory infection or chronic lung disease
• Sick sinus syndrome or atrioventricular block
• Preoperative anemia (hemoglobin < 90 g/L)

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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60 participants in 3 patient groups, including a placebo group

Placebo group

Placebo Comparator group

Description:

Placebo group received an equivalent volume of 0.9% saline.

Treatment:

Drug: 0.9 % saline

dexmedetomidine Low Dose group

Experimental group

Description:

Following Anesthesia induction, dexmedetomidine (DEX) Low Dose group received a DEX loading dose (0.5 µg/kg over 10 min), followed by continuous infusions of 0.3 µg/kg/h, respectively, until 30 minutes before the end of the operation.

Treatment:

Drug: dexmedetomidine 0.3 µg/kg/h

dexmedetomidine high dose group

Experimental group

Description:

Following Anesthesia induction, dexmedetomidine (DEX) high dose group received a DEX loading dose (0.5 µg/kg over 10 min), followed by continuous infusions of 0.5 µg/kg/h, respectively, until 30 minutes before the end of the operation.

Treatment:

Drug: dexmedetomidine 0.5 µg/kg/h