Dexmedetomidine for Catheter-related Bladder Discomfort (CRBDEX)

Seoul National University

Status and phase: Unknown; Phase 4

Conditions: Vomiting; Nausea; Arrhythmia; Pain; Blood Pressure

Treatments: Drug: NS infusion; Drug: Dex infusion

Study type: Interventional

Funder types: Other

Identifiers

NCT01991223

CRBD_SNUH1 (Other Grant/Funding Number)

CRBD_DEX_PHPKHC

Details and patient eligibility

About

To evaluate the efficacy of dexmedetomidine for the prevention of catheter-related bladder discomfort

Full description

After transurethral bladder resection, large-sized foley catheter have been used for drainage of urine and residual blood. Because of urinary catheterization, patients usually experiences catheter-related bladder discomfort defined as a burning sensation with an urge to void or discomfort in the supra-pubic region caused by catheter- related bladder irritation.

Dexmedetomidine is an alpha-2 antagonist and used as an analgesic agent. The investigators try to evaluate The efficacy of dexmedetomidine for the treatment of catheter-related bladder discomfort

Enrollment: 114 estimated patients

Sex: All

Ages: 19 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients scheduled for transurethral bladder resection
• ASA I-III

Exclusion criteria

• Patient who disagrees to participate this investigation
• Patient with severe cardiovascular disease
• Patient with small-sized foley catheter (less than 18 Fr.)
• Patinets with any urinary tract obstructions
• Patient with hyperactive or neurogenic bladder
• Patients with chronic renal failure
• Patient with morbidly obese
• Patients with neurogenic disorder
• Patient with medications for chronic pain

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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114 participants in 2 patient groups, including a placebo group

Placebo group

Placebo Comparator group

Description:

NS infusion will be done during surgery.

Treatment:

Drug: NS infusion

Dex group

Experimental group

Description:

DEX infusion will be done during surgery.

Treatment:

Drug: Dex infusion