Dexmedetomidine for ESPB in Pain Management After Pediatric Idiopathic Scoliosis Surgery

Poznan University of Medical Sciences (PUMS)

Status and phase: Not yet enrolling; Phase 4

Conditions: Scoliosis; Adolescence; Scoliosis; Scoliosis Idiopathic

Treatments: Drug: 0.9%NaCl; Drug: Dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT06789016

12/2024

Details and patient eligibility

About

Effect of perineurial dexmedetomidine on erector spinal plane block duration for pediatric, idiopathic scoliosis surgery.

Full description

This study proposes to explore the effect of perineurial Dexmedetomidine on the duration of erector spinal plane block for pediatric idiopathic scoliosis surgery.

Children need good analgesia after scoliosis surgery. Peripheral nerve blocks have provided a safe, effective method to control early postoperative pain when symptoms are most severe.

The safety of local anesthesia is essential in children due to the much lower toxicity threshold of local anesthetics. An effective adjuvant, such as Dexmedetomidine, could allow for a higher dilution of local anesthetics while maintaining and enhancing their analgesic effect.

Enrollment: 60 estimated patients

Sex: All

Ages: 10 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• children scheduled for idiopathic scoliosis surgery
• age >10 and <18 years

Exclusion criteria

• age < 10 years
• age < 18 years
• infection at the site of the regional blockade
• coagulation disorders
• immunodeficiency
• ASA= or >4
• steroid medication in regular use

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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60 participants in 2 patient groups

DEXMEDETOIDINE

Active Comparator group

Description:

0.2% ropivacaine 0.5ml/kg+ 0.1ug/kg Dexamethasone for erector spinae plane block

Treatment:

Drug: Dexmedetomidine

CONTROL

Active Comparator group

Description:

0.2% ropivacaine 0.5ml/kg for erector spinae plane block

Treatment:

Drug: 0.9%NaCl