Dexmedetomidine Improves Recovery After Cranial Aneurysm Surgery (DACA)

Z

Zhihong LU

Status

Completed

Conditions

Aneurysm Cerebral

Treatments

Drug: nasal saline
Drug: nasal dexmedetomidine
Drug: Intravenous dexmedetomidine
Drug: intravenous saline

Study type

Interventional

Funder types

Other

Identifiers

NCT03355534
XJH-A-2017-10-10

Details and patient eligibility

About

Dexmedetomidine induces analgesic and sedative effects and is reported to decrease agitation during emergence after general anesthesia in various surgeries. For patients undergoing cranial aneurysm surgeries, a calm anesthesia and emergence is important. In this study, the investigatorstend to observe the effect of dexmedetomidine on maintenance and recovery of patients undergoing cranial aneurysm surgeries.

Enrollment

150 patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

patients undergoing cerebral aneurysm embolism under general anesthesia

Exclusion criteria

  • patients with bradycardia or atrioventricular heart block
  • patients with ASA(American Society of Anesthesiologists) status over 3
  • patients with body mass index(BMI)≥30kg/m2
  • patients with difficulty in communication
  • patients with ruptured aneurysm
  • patients suspected or proved to be pregnant

Trial design

150 participants in 3 patient groups, including a placebo group

nasal dexmedetomidine
Experimental group
Description:
dexmedetomidine is given nasally, saline is given intravenously
Treatment:
Drug: intravenous saline
Drug: nasal dexmedetomidine
intravenous dexmedetomidine
Experimental group
Description:
saline is given nasally, dexmedetomidine is given intravenously
Treatment:
Drug: Intravenous dexmedetomidine
Drug: nasal saline
normal saline
Placebo Comparator group
Description:
saline is given nasally and intravenously
Treatment:
Drug: intravenous saline
Drug: nasal saline

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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