Dexmedetomidine in Spinal Anesthesia

Inje University

Status: Completed

Conditions: Anxiety; Blood Pressure

Treatments: Drug: Dexmedetomidine; Drug: Dexmedetomidine with heavy bupivacaine

Study type: Interventional

Funder types: Other

Identifiers

NCT02155010

2014-003

Details and patient eligibility

About

Patients were randomized into two groups, A group and B group. A group and B group patients are injected intravenous dexmedetomidine after intrathecal injection (IT) of heavy bupivacaine and injected intravenous dexmedetomidine before IT of heavy bupivacaine, respectively.

The investigators will compare of hemodynamics and patient's comfortability between two groups.

Full description

A and B group patients will intravenous inject dexmedetomidine 1mcg/kg for 10 minute loading infusion and 0.2mcg/kg/hr for continuous infusion. A group receive intravenous dexmedetomidine after procedure, and B group receive intravenous dexmedetomidine before procedure. Both group patients will hydrate 6 ml/kg crystalloid solution and will evaluated patient's anxiety and comfortability perioperative period. Vital signs will record 5 minutes interval at operating room and post-anesthetic care units.

Enrollment: 74 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 20 - 60 aged patients
• orthopedic operation undergoing spinal anesthesia

Exclusion criteria

• more than American society of anesthesiologists classification 3
• hypertension
• diabetes mellitus
• heart disease (bradycardia, atrioventricular block)

Trial design

74 participants in 2 patient groups

Dexmedetomidine

Experimental group

Description:

IV dexmedetomidine infusion before intrathecal injection of heavy bupivacaine

Treatment:

Drug: Dexmedetomidine

Dexmedetomidine with heavy bupivacaine

Active Comparator group

Description:

IV dexmedetomidine infusion after intrathecal injection of heavy bupivacaine

Treatment:

Drug: Dexmedetomidine with heavy bupivacaine