Dexmedetomidine Influence on the Level of Perioperative Blood Glucose and Insulin of Elderly Diabetes Patients

Xi'an Jiaotong University

Status and phase: Unknown; Phase 4

Conditions: Perioperative Blood Glucose and Insulin

Treatments: Drug: Dexmedetomidine; Drug: general anesthesia induction; Drug: normal saline; Drug: Isoflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT02154074

Dexmedetomidine 20140527

Details and patient eligibility

About

Dexmedetomidine is a kind of high selectivity alpha 2 agonists adrenaline, can inhibit the activity of sympathetic nerve, alleviate pain,and improve cardiovascular stability in the operation period. Dexmedetomidine have influence on perioperative stress response and immune function,but it is not clear.

Enrollment: 92 estimated patients

Sex: All

Ages: 60 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged 60 to 80 years old;
• Type 2 diabetes;
• Not use insulin treatment;
• Onging general anesthesia surgery;
• Surgery time 1-3 hours

Exclusion criteria

• ASA classification > class II;
• Hypertension;
• Serious central nervous system diseases (acute stroke, uncontrolled seizures, -Severe dementia);
• Unstable angina and acute myocardial infarction;
• Allergy to investigational drug;
• Hepatic and renal dysfunction

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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92 participants in 4 patient groups

N1 group: Isoflurane & saline

Active Comparator group

Description:

for normal patients: inhale Isoflurane + the same volume of saline during operation

Treatment:

Drug: normal saline

Drug: general anesthesia induction

Drug: Isoflurane

N2 group: Isoflurane & Dexmedetomidine

Experimental group

Description:

for normal patients: inhale Isoflurane + intravenous pumping Dexmedetomidine during operation

Treatment:

Drug: Dexmedetomidine

Drug: general anesthesia induction

Drug: Isoflurane

D1 group: Isoflurane & saline

Active Comparator group

Description:

for diabetes patients: inhale Isoflurane + the same volume of saline during operation

Treatment:

Drug: normal saline

Drug: general anesthesia induction

Drug: Isoflurane

D2 group: Isoflurane & Dexmedetomidi

Experimental group

Description:

for diabetes patients: inhale Isoflurane + intravenous pumping Dexmedetomidine during operation

Treatment:

Drug: Dexmedetomidine

Drug: general anesthesia induction

Drug: Isoflurane