Dexmedetomidine-ketamine in Femur Proximal Fracture Patients

Inje University

Status: Completed

Conditions: Pain

Treatments: Drug: Fentanyl; Drug: Ketamine; Drug: Dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT02150759

2014-027

Details and patient eligibility

About

• Comparison study of analgesic effects for dexmedetomidine-fentanyl vs dexmedetomidine-ketamine
• lateral position for spinal anesthesia in femur proximal fracture patients

Full description

• Dexmedetomidine (1mcg/kg)- fentanyl (1mcg/kg) vs dexmedetomidine (1mcg/kg) - ketamine (1mg/kg) 10 minutes loading.
• After 10 minutes of drug infusion, patients are prepared for spinal anesthesia.
• pain scale and quality of patient positioning are measured three times (lateral position, chest-knee position, intrathecal local anesthetics injection)
• When patients have severe pain during intraoperative period, fentanyl 50 mcg will be intravenously inject.
• Patients will be injected propofol 10mg when they have agitation signs during operation.
• vital signs, bispectral index, korean version of mini mental status examination, verbal rating scale,fentany/propofol consumption, frequency of intrathecal injection

Enrollment: 46 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American society of anesthesiologists classification 1-3 patients
• >20 years old

Exclusion criteria

• patients refuse
• dementia patients, cooperation difficult patients
• anaphylaxis of dexmedetomidine, ketamine, local anesthetics
• heart problem (bradycardia, atrioventricular block)

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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46 participants in 2 patient groups

Dexmedetomidine-ketamine

Experimental group

Description:

Dexmedetomidine-ketamine group

Treatment:

Drug: Dexmedetomidine

Drug: Ketamine

Dexmedetomidine-fentanyl

Active Comparator group

Description:

Dexmedetomidine-fentanyl group

Treatment:

Drug: Dexmedetomidine

Drug: Fentanyl