Dexmedetomidine Nebulization for Attenuation of Pressor Response to Laryngoscopy and Endotracheal Intubation in Sever Preeclamptic Patients

Assiut University

Status: Not yet enrolling

Conditions: Pressor Response

Treatments: Drug: Saline; Drug: Dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT07164326

Dexmedetomidine nebulization

Details and patient eligibility

About

Dexmedetomidine nebulization in sever preeclamptic patients

Full description

Dexmedetomidine nebulization for attenuation of pressor response to laryngoscopy and endotracheal intubation in sever preeclamptic patients undergoing caesarean section under general anaesthesia. A prospective randomized clinical trial.

Enrollment: 100 estimated patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with severe pre-eclampsia scheduled for cesarean section under general anesthesia
• ASA II, III

Exclusion criteria

• sever obesity (BMI ≥ 40)
• Cardiac patients
• History of diabetes mellitus
• Renal dysfunction (elevated serum creatinine > 2mg\dl)
• hepatic dysfunction (elevated hepatic enzyme three times above normal)
• History to hypersensitivity to the tested drug.
• Emergency surgery
• Known fetal anomalies

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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100 participants in 2 patient groups, including a placebo group

Dexmedetomidine

Experimental group

Description:

Nebulization of dexmedetomidine

Treatment:

Drug: Dexmedetomidine

Saline

Placebo Comparator group

Description:

Nebulization of saline

Treatment:

Drug: Saline