Dexmedetomidine on Optic Nerve Sheath Diameter

Gachon University Gil Medical Center

Status: Withdrawn

Conditions: Intracranial Hypertension

Treatments: Drug: normal saline; Drug: Dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT02753205

GCIRB2016-058

Details and patient eligibility

About

Dexmedetomidine, might attenuate the sympathetic activation and contribute to stable hemodynamics. The investigator hypothesized that continuous infusion of dexmedetomidine during laparoscopic lower abdominal surgery, might help to attenuate the increment of intracranial pressure and the investigator would observe the optic nerve sheath diameter using ultrasonography.

Full description

Laparoscopic lower abdominal surgery requires the Trendelenburg position with pneumoperitoneum for a prolonged time, but this can cause significant increase in intracranial pressure. Dexmedetomidine, a selective alpha2 receptor agonist might attenuate the sympathetic activation and contribute to stable hemodynamics. The investigator hypothesized that continuous infusion of dexmedetomidine during laparoscopic lower abdominal surgery, might help to attenuate the increment of intracranial pressure and the investigator would observe the optic nerve sheath diameter using ultrasonography.

Sex: All

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• clinical diagnosis of colorectal cancer
• planed for laparoscopic low anterior resection

Exclusion criteria

• morbid obesity (body mass index > 30 kg.m-2)
• history of cerebrovascular disease
• history of respiratory disease
• uncontrolled cardiovascular disease

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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0 participants in 2 patient groups

Control

Experimental group

Description:

Infusion of normal saline

Treatment:

Drug: normal saline

Dexmedetomidine

Active Comparator group

Description:

infusion of dexmedetomidine 0.5ug/kg/h for 10 min and after that, infusion of dexmedetomidine 0.4ug/kg/h until the end of surgery

Treatment:

Drug: Dexmedetomidine