Dexmedetomidine on Segmental EEG Power Spectra

Zhiyi Zuo

Status: Unknown

Conditions: Anesthesia; EEG Power Spectra

Study type: Observational

Funder types: Other

Identifiers

NCT03515876

2018-52

Details and patient eligibility

About

To compare the EEG power spectra activity during propofol-based anesthesia in the presence or absence of dexmedetomidine in patients undergoing hysteroscopic examination and surgery to determine whether the addition of dexmedetomidine will induce better sleep-like anesthesia status.

Full description

Three groups of patients undergoing hysteroscopic examination and surgery will be studied: 1) control group, patients will receive propofol intravenous infusion to provide anesthesia; 2) dexmedetomidine 0.5 microgram/kg group. This dexmedetomidine dose is infused within 10 min and then the use of propofol for anesthesia; and 3) dexmedetomidine 1 microgram/kg group. This dexmedetomidine dose is infused within 10 min and then the use of propofol for anesthesia.

Each group will have 20 patients.

General conditions including blood pressure, respiration, and heart rates will be recorded.

EEG power spectra activity will be recorded no-invasively by a Narcotrend EEG monitor.

Enrollment: 60 estimated patients

Sex: Female

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists Physical status I to II grade.
• body mass index 18 to 25 kg/m2
• no vision or hearing impairment
• will receive general anesthesia

Exclusion criteria

• with psychological or mental diseases
• with neurological diseases
• treating with steroids or with alcohol dependence.

Trial design

60 participants in 3 patient groups

Control

Description:

Patients will receive intravenous propofol infusion.

Dexmedetomidine 0.5 microgram/kg group

Description:

Patients will receive dexmedetomidine 0.5 microgram/kg and then intravenous propofol infusion.

Dexmedetomidine 1 microgram/kg group

Description:

Patients will receive dexmedetomidine 1 microgram/kg and then intravenous propofol infusion.