Dexmedetomidine to Improve Outcomes During Emergence From Retroperitoneal Laparoscopic Surgery (DEALS)

Air Force Military Medical University of People's Liberation Army

Status: Completed

Conditions: Anesthesia

Treatments: Other: loading dose; Other: sustaining dose; Drug: dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT02316236

XJH-A-2014-6-22-01

Details and patient eligibility

About

The study is to observe whether dexmedetomidine could reduce agitation during emergence from general anesthesia in patients undergoing retroperitoneal laparoscopic surgery.

Full description

Agitation during emergence is frequent after retroperitoneal urologic surgery. Dexmedetomidine is alpha-2 receptor agonist which shows sedative and algesic effect. In this study we will compare the effect of dexmedetomidine given by different protocols on emergence agitation.

Enrollment: 66 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients scheduled for retroperitoneal laparoscopic surgery
• Patients with written informed consent

Exclusion criteria

• Patients with difficulty of communication
• Patients with risk of obstructive sleeping apnea syndrome

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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66 participants in 2 patient groups

dexmedetomidine loading dose

Experimental group

Description:

dexmedetomidine is given at load dose

Treatment:

Drug: dexmedetomidine

Other: loading dose

dexmedetomidine sustaining dose

Experimental group

Description:

dexmedetomidine is given at sustaining dose

Treatment:

Drug: dexmedetomidine

Other: sustaining dose